Vous trouverez dans cette rubrique les offres de stage, de thèses, de post doctorats, de CDD et CDI à pourvoir dans les laboratoires partenaires du réseau.

Liste des annonces

2018/10/02- Post-doctoral position: MR-Guided Focused Ultrasound in experimental model (18 months)

A full-time18-month postdoctoral position is available at the Center for Neuroimaging Research (CENIR) at ICM (Paris) in collaboration with the Institut Langevin (Paris) and the Neurodegenerative Diseases Research Group (Barcelona, Spain) to work on a new project recently funded by the Agence Nationale pour la Recherche (ANR) untitled “Focused ultrasound modulation of neuromelanin (NM) accumulation in a humanized murine model of Parkinson’s disease (PD)”. The goal of the project is to evaluate whether transcranial focused ultrasound (tFUS), an emerging non-invasive technology, can lower NM levels below their pathogenic threshold in NM-producing PD experimental models and prevent, halt or delay neuronal dysfunction and degeneration. If successful, this proposal will lay the groundwork for the development of a novel disease-modifying therapy for PD based on the modulation of NM levels with tFUS. CENIR is the ICM’s neuroimaging platform directed by Pr. Stéphane Lehéricy. This imaging facility consists primarily of human MRI scanners (3T), a small animal MRI scanner (Bruker Biospec 117/16 USR) equipped with an Image Guided Therapy (IGT) ultrasound system, and MEG, EEG, TMS and PET/MRI systems to study brain structure and function in normal and pathological conditions. Institut Langevin is expert in focused ultrasound technology (Drs. Jean-Francois Aubry and Michael Tanter).
The overall project will involve transversal collaborations between experts in PD, experimental models, MRI and ultrasounds, cellular imaging and histology within and outside the Institute. Pr. Miquel Vila is the principal investigator at the Neurodegenerative Diseases Research Group (Barcelona, Spain) and has developed the NM-producing PD experimental models.
The post-doctoral fellow will be involved in methodological developments of this new approach to trigger and enhance NM clearance. In this framework, the candidate will oversee the acquisition and analysis of data at 11.7T in murine model of Parkinson’s disease. He/She might also be involved in behavioral and histological studies.

Recruitment starting date: October 2018

2018/07/05 – PhD student – Functional Renal Magnetic Resonance Imaging, Geneva

You will be responsible for the acquisition and analysis of renal MRI exams in chronic kidney patients scheduled before their renal biopsy in the 2 centers (Geneva and Lausanne) in collaboration with Dr Menno Pruijm and Pr H. Thoeny. You will develop MR pulse sequences and reconstruction algorithms as well as work on the optimisation of a multiparametric renal MR acquisition protocol. Using the expertise available in the EU COST network, advanced analysis tools in this patient cohort will also be developed. You will work closely with radiologists and nephrologists to interpret the data. You will be located in Geneva but you will travel once a week to Lausanne and Fribourg according to the patient recruitment.

Four year PhD program, full time position, starting in September 2018.

2018/ 06 /28- Research Associate in Medical Image Research (48 months)

SPCCT research Associate in Medical Image Research position requires an individual who is professional, self-learner, with can-do approach, team player with good communication skills. In this role, you will be part of an international research team that is developing a new spectral photon counting CT system (SPCCT).
Responsibilities :
Responsible for preclinical and clinical project of the SPCCT and the IQon system:
- Coordinate and execute research plans performed on both systems.
- Organize all experimental Animal and Human studies described in the European Project Horizon 2020 involving the SPCCT and IQon according to the relevant French, European Union and International legislations (ethical committee, IRB etc)
- Assist scanning of humans when part of clinical research projects
- Conduct quality assurance for scanner performance; identify and escalate system problems to appropriate staff
- Managing all images transferred/stored in PACS or other archival systems

2018/06/13 – CDD Spécialiste en traitement des images RMN

Au sein du laboratoire de RMN du Neuromuscular Investigation Center, vous serez en charge des aspects de post‐traitement des données, autant pour le développement de nouvelles techniques que pour la mise en place de méthodes fiables pour le suivi des patients.
Développer ou améliorer des méthodes de post‐traitement d’imagerie par RMN pour  le cas spécifique des muscles. 
Contribuer  à  l’amélioration  des  techniques  d’acquisition,  notamment  par  l’implémentation  de  méthodes  modernes  de  reconstruction  d’images  de  type  compressed sensing et fingerprinting. 
Garantir la qualité des mesures réalisées dans le cadre d’études cliniques par la mise en place et le maintien d’outils informatiques pour le suivi des patients par des méthodes quantitatives.  

CDD temps plein de 18 mois

Associate Scientist – Postdoctoral position, Lyon Area

This post-doctorate (18 months contract) is dedicated to develop in vivo imaging techniques to increase speed end robustness of the evaluation of new vaccines and adjuvants, especially in term of efficacy and bio-distribution.

Identify bio-markers, immune cells and pathways in order to assess the bio-distribution of the components in collaboration with IDMIT (Infectious Disease Models for Innovative Therapies).
Design and perform in vivo imaging studies for mRNA vaccines and new adjuvants projects in collaboration with RNCS (Research and Non Clinical Safety) teams.
This includes:
- Tag specific bio-markers, antigens and adjuvants.
- Design and perform in vitro studies to validate the techniques
For in vivo studies:
- Design experiments and draft protocols. Ask the authorization to the ethics committee
- Realize the in vivo phase on rodents or Non-Human Primates
- Analyze data with dedicated tools (like Living image software) and write appropriate reports
- Present conclusions to internal scientific committees
- Support in vivo imaging activities for other high prioritized projects
- Be a referent for technical aspects on in vivo imaging technologies like manage relationships with the supplier (PerkinElmer) of the IVIS Spectrum CT in Marcy L’Etoile (optical + 3D computerized tomography imaging), organize and monitor regular maintenance and decontaminations of the bioimaging laboratory and imaging devices.
- Support the development of in vivo Confocal Laser Endo-microscopy within Sanofi Pasteur with for example the Cellvizio Lab system from Mauna Kea to be tested on site.

Level 2 and 3 bio-containment facilities with a significant diversity of housed species (rodents and non-rodents) involving compliance to:
- rules of hygiene and safety of the sites
- procedures concerning the welfare and environment of animals
- French and European legislation concerning housing and experimentation on animals
- Sanofi charter on the protection of animals
- High technology level in vivo imaging devices to manage including:
a Photon Imager from Biospace lab with bioluminescence and fluorescence optical imaging modalities
an IVIS Spectrum CT from PerkinElmer with optical modalities associated with X ray computerized tomography allowing 3 dimensions imaging.
This device requires radiation protection management and regular inspections by the French Nuclear Safety Agency, external controls, and internal radiation monitoring.
Note that there is a potential use of radio-labelled compounds in the CEA with specific regulation and security procedures.
The candidate needs an important customer orientation (RNCS & ARD) to be an effective technical and scientific support in bioimaging within the framework of R&D projects, taking into account the organization, objectives and projects of the AMB platform.

This position will have interactions with many people mainly within:
- RNCS in Marcy l’Etoile
- IDMIT: this includes potential periods during the mission when the Post-doctorate will have to work in the IDMIT center in Fontenay-aux-Roses.
- RNCS in Cambridge (mRNA projects)

2018/06/07 – CDD responsable pédagogique du Diplôme de qualification en physique radiologique et médicale

Le DQPRM est un diplôme délivré par l'INSTN en partenariat avec la Société française de physique médicale
D'une durée de 28 mois, il a pour but de former des personnes spécialisées en radiophysique médicale
(PSRM) dont la mission principale est de garantir la qualité et la sécurité de l'utilisation médicale des
rayonnements ionisants.
La formation et les missions des PSRM sont définies dans l'arrêté du 6 décembre 2011 modifiant l'arrêté du
19 novembre 2004. Le DQPRM satisfait aux exigences de l'article 4 de cet arrêté et permet à ses titulaires
d'exercer en milieu hospitalier en tant que personne spécialisée en radiophysique médicale.
En tant que responsable pédagogique de cet enseignement, vous garantissez le respect des dispositions
réglementaires qui le concernent, de l'organisation du concours aux examens finaux, en passant par la mise
en oeuvre des cours et des stages obligatoires dans des centres agréés.
Vous contribuez à l'évolution du diplôme dont les nouvelles modalités seront applicables dès la rentrée 2019.
Vous gérez également le module radioprotection du master de physique médicale pour lequel vous être en
lien avec l'université Paris-Saclay..
Enfin, vous enseignez votre thématique dans ces formations, voire d'autres si besoin.
Durée: 12 mois.

2018/06/04 – Contrat postdoctoral en biologie dans la cadre du projet Européen H2020 IDentIFY à Grenoble

Le projet Européen H2020 IDentIFY (Improving Diagnosis by Fast Field Cycling MRI) réunit 8 laboratoires et 2 industriels de 6 pays : France, Angleterre, Italie, Allemagne, Pologne et Finlande. C’est un projet de technologies pour la santé qui a pour buts (i) de construire une IRM à champ magnétique faible et variable, dit IRM à champ magnétique cyclique, (ii) d’apporter la preuve du concept de cette nouvelle technologie en médecine et (iii) de modéliser les signaux pour les associer à des paramètres biologiques dont les variations reflètent des processus physiopathologiques. Cette technologie donne des informations sur la dynamique moléculaire de l’eau dans le nano/microenvironnement du tissu exploré, une information invisible par les méthodes RMN/IRM conventionnelles à champ magnétique fixe et de valeur élevée.
A Grenoble nous disposons d'un champ magnétique cyclique (un des rares en France), installé à l’INAC (Institut des NAnosciences et Cryogénie) au CEA et notre activité est centrée sur l’étude des cancers agressifs comme celui du cerveau et du sein. Nous travaillons sur des lignées de cellules tumorales, des exérèses humaines, des tumeurs de modèles animaux ou encore sur des solutions/tissus synthétiques pour moduler une fonction physiologique
donnée, pour des études fondamentales. Le but in fine est de montrer dans quelle mesure les paramètres des signaux acquis en RMN à champ magnétique cyclique (signaux de relaxométrie) sont des biomarqueurs différentiant la région tumorale de la péritumorale et cette dernière de la région saine. La question clé est d’élucider les corrélât biologiques sous-jacents aux signaux physiques de relaxométrie.

Fonction : Mise en place et conduite des expériences biologiques fonctionnelles pour comprendre le rôle de la dynamique moléculaire de l’eau dans le processus du cancer et ses interactions avec les protéines.

Contrat: un an, voire 18 mois (selon date du début de la fonction), disponible dès à présent.

2018/03/22 – PhD fellowship: region-of-interest CT reconstruction for dose reduction, Lyon

The purpose of this PhD fellowship is to develop and analyze inversion algorithms for ROI reconstruction to obtain equivalent image quality compared to a full field-of-view CT. Both analytic and iterative reconstruction techniques will be investigated. There is currently no known analytic solution but the problem can be linked to the inversion of the one-dimensional (1D) truncated Hilbert transform which has a unique stable solution [3]. Instead, one can also do a conventional two-dimensional (2D) or three-dimensional (3D) iterative CT reconstruction [2].

The PhD fellow will approach both types of solutions for ROI CT reconstruction. First, he/she will investigate a numerical inversion of the truncated 1D Hilbert transform. Second, existing iterative reconstruction algorithms will be adpated to ROI CT. The investigations should determine under which circumstances equivalent image quality can be reached. The developments will use and enhance the Reconstruction Toolkit (RTK, http://www.openrtk.org/).

[1] R. Clackdoyle and M. Defrise. Tomographic reconstruction in the 21st century. region-of-interest reconstruction from incomplete data. 27(4):60–80, 2010.
[2] R. Clackdoyle, F. Noo, F. Momey, L. Desbat, and S. Rit. Accurate transaxial region-of-interest reconstruction in helical CT? IEEE Transactions on Radiation and Plasma Medical Sciences, 1(4):334–345, July 2017.
[3] M. Defrise, F. Noo, R. Clackdoyle, and H. Kudo. Truncated Hilbert transform and image reconstruction from limited tomographic data. Inverse problems, 22(3):1037, 2006.

Period: three years starting in 2018.
More information : https://www.creatis.insa-lyon.fr/site7/sites/www.creatis.insa-lyon.fr/files/2018_phd_roidore_1.pdf

2018/03/20 – Post-doctoral position in multiparametric MRI of nonalcoholic steatohepatitis, LBI-CRI, Paris

Quantitative MRI offers promise in the diagnosis of inflammation and fibrosis in patients with nonalcoholic steatohepatitis (NASH), a frequent complication in type 2 diabetes. The Quid-NASH project in our laboratory aims to develop and validate multimodal non-invasive biomarkers of NASH which will result in a "virtual liver biopsy". Particularly, MR imaging will be used to provide physical quantification of mechanical properties, proton density fat fraction and derived metrics, magnetic susceptibility, water diffusivity, T2 and T1 relaxation times. Moreover, in small animal models of NASH, MRI will be combined with simultaneously acquired ultrafast ultrasound imaging in a hybrid approach. Radiomic analysis and heterogeneous data integration will be part of the project.
The successful candidate will play a key role in the clinical and preclinical studies of the Quid-NASH project. The candidate will be in charge of the development and optimization of the advanced image acquisition procedures. The candidate will ensure rigorous scientific conditions throughout the clinical trial and the small animal studies by interacting with the clinicians and scientists in the project.
The position has a 12-month initial employment basis and is renewable.

2018/03/20 – Post-doctoral position in radiomics of liver diseases, LBI – CRI, Paris

With high-throughput computing, it is now possible to extract innumerable quantitative features from MR images. Moreover, image data are increasingly interpreted in light of complementary data coming from other modalities, including genomics, transcriptomics and metabolomics. Thus, novel challenges in terms of data extraction, analysis and integration are emerging in the field. In response, novel methods such as machine learning or generalized statistical tools are gaining acceptance in the scientific and medical communities.
In this context, the proposed position involves the development, implementation and validation of novel post-processing methods of MR images to obtain imaging biomarkers of chronic liver diseases and liver tumors.
The position has a 12-month initial employment basis and is renewable.

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