FLI
In this section, you will find internships, thesis, post-doctorates, fixed-term and permanent contract vacancies in the network’s partner laboratories.
Liste des annonces
2018/10/02- Post-doctoral position: MR-Guided Focused Ultrasound in experimental model (18 months)
A full-time18-month postdoctoral position is available at the Center for Neuroimaging Research (CENIR) at ICM (Paris) in collaboration with the Institut Langevin (Paris) and the Neurodegenerative Diseases Research Group (Barcelona, Spain) to work on a new project recently funded by the Agence Nationale pour la Recherche (ANR) untitled “Focused ultrasound modulation of neuromelanin (NM) accumulation in a humanized murine model of Parkinson’s disease (PD)”. The goal of the project is to evaluate whether transcranial focused ultrasound (tFUS), an emerging non-invasive technology, can lower NM levels below their pathogenic threshold in NM-producing PD experimental models and prevent, halt or delay neuronal dysfunction and degeneration. If successful, this proposal will lay the groundwork for the development of a novel disease-modifying therapy for PD based on the modulation of NM levels with tFUS. CENIR is the ICM’s neuroimaging platform directed by Pr. Stéphane Lehéricy. This imaging facility consists primarily of human MRI scanners (3T), a small animal MRI scanner (Bruker Biospec 117/16 USR) equipped with an Image Guided Therapy (IGT) ultrasound system, and MEG, EEG, TMS and PET/MRI systems to study brain structure and function in normal and pathological conditions. Institut Langevin is expert in focused ultrasound technology (Drs. Jean-Francois Aubry and Michael Tanter).
The overall project will involve transversal collaborations between experts in PD, experimental models, MRI and ultrasounds, cellular imaging and histology within and outside the Institute. Pr. Miquel Vila is the principal investigator at the Neurodegenerative Diseases Research Group (Barcelona, Spain) and has developed the NM-producing PD experimental models.
The post-doctoral fellow will be involved in methodological developments of this new approach to trigger and enhance NM clearance. In this framework, the candidate will oversee the acquisition and analysis of data at 11.7T in murine model of Parkinson’s disease. He/She might also be involved in behavioral and histological studies.
Recruitment starting date: October 2018
2018/10/02- Post-doctoral position: MR-Guided Focused Ultrasound in experimental model (18 months)
A full-time18-month postdoctoral position is available at the Center for Neuroimaging Research (CENIR) at ICM (Paris) in collaboration with the Institut Langevin (Paris) and the Neurodegenerative Diseases Research Group (Barcelona, Spain) to work on a new project recently funded by the Agence Nationale pour la Recherche (ANR) untitled “Focused ultrasound modulation of neuromelanin (NM) accumulation in a humanized murine model of Parkinson’s disease (PD)”. The goal of the project is to evaluate whether transcranial focused ultrasound (tFUS), an emerging non-invasive technology, can lower NM levels below their pathogenic threshold in NM-producing PD experimental models and prevent, halt or delay neuronal dysfunction and degeneration. If successful, this proposal will lay the groundwork for the development of a novel disease-modifying therapy for PD based on the modulation of NM levels with tFUS. CENIR is the ICM’s neuroimaging platform directed by Pr. Stéphane Lehéricy. This imaging facility consists primarily of human MRI scanners (3T), a small animal MRI scanner (Bruker Biospec 117/16 USR) equipped with an Image Guided Therapy (IGT) ultrasound system, and MEG, EEG, TMS and PET/MRI systems to study brain structure and function in normal and pathological conditions. Institut Langevin is expert in focused ultrasound technology (Drs. Jean-Francois Aubry and Michael Tanter).
The overall project will involve transversal collaborations between experts in PD, experimental models, MRI and ultrasounds, cellular imaging and histology within and outside the Institute. Pr. Miquel Vila is the principal investigator at the Neurodegenerative Diseases Research Group (Barcelona, Spain) and has developed the NM-producing PD experimental models.
The post-doctoral fellow will be involved in methodological developments of this new approach to trigger and enhance NM clearance. In this framework, the candidate will oversee the acquisition and analysis of data at 11.7T in murine model of Parkinson’s disease. He/She might also be involved in behavioral and histological studies.
Recruitment starting date: October 2018
2018/07/05 – PhD student – Functional Renal Magnetic Resonance Imaging, Geneva
You will be responsible for the acquisition and analysis of renal MRI exams in chronic kidney patients scheduled before their renal biopsy in the 2 centers (Geneva and Lausanne) in collaboration with Dr Menno Pruijm and Pr H. Thoeny. You will develop MR pulse sequences and reconstruction algorithms as well as work on the optimisation of a multiparametric renal MR acquisition protocol. Using the expertise available in the EU COST network, advanced analysis tools in this patient cohort will also be developed. You will work closely with radiologists and nephrologists to interpret the data. You will be located in Geneva but you will travel once a week to Lausanne and Fribourg according to the patient recruitment.
Four year PhD program, full time position, starting in September 2018.
2018/07/05 – PhD student – Functional Renal Magnetic Resonance Imaging, Geneva
You will be responsible for the acquisition and analysis of renal MRI exams in chronic kidney patients scheduled before their renal biopsy in the 2 centers (Geneva and Lausanne) in collaboration with Dr Menno Pruijm and Pr H. Thoeny. You will develop MR pulse sequences and reconstruction algorithms as well as work on the optimisation of a multiparametric renal MR acquisition protocol. Using the expertise available in the EU COST network, advanced analysis tools in this patient cohort will also be developed. You will work closely with radiologists and nephrologists to interpret the data. You will be located in Geneva but you will travel once a week to Lausanne and Fribourg according to the patient recruitment.
Four year PhD program, full time position, starting in September 2018.
2018/ 06 /28- Research Associate in Medical Image Research (48 months)
SPCCT research Associate in Medical Image Research position requires an individual who is professional, self-learner, with can-do approach, team player with good communication skills. In this role, you will be part of an international research team that is developing a new spectral photon counting CT system (SPCCT).
Responsibilities :
Responsible for preclinical and clinical project of the SPCCT and the IQon system:
- Coordinate and execute research plans performed on both systems.
- Organize all experimental Animal and Human studies described in the European Project Horizon 2020 involving the SPCCT and IQon according to the relevant French, European Union and International legislations (ethical committee, IRB etc)
- Assist scanning of humans when part of clinical research projects
- Conduct quality assurance for scanner performance; identify and escalate system problems to appropriate staff
- Managing all images transferred/stored in PACS or other archival systems
2018/ 06 /28- Research Associate in Medical Image Research (48 months)
SPCCT research Associate in Medical Image Research position requires an individual who is professional, self-learner, with can-do approach, team player with good communication skills. In this role, you will be part of an international research team that is developing a new spectral photon counting CT system (SPCCT).
Responsibilities :
Responsible for preclinical and clinical project of the SPCCT and the IQon system:
- Coordinate and execute research plans performed on both systems.
- Organize all experimental Animal and Human studies described in the European Project Horizon 2020 involving the SPCCT and IQon according to the relevant French, European Union and International legislations (ethical committee, IRB etc)
- Assist scanning of humans when part of clinical research projects
- Conduct quality assurance for scanner performance; identify and escalate system problems to appropriate staff
- Managing all images transferred/stored in PACS or other archival systems
2018/06/13 – CDD Spécialiste en traitement des images RMN
Au sein du laboratoire de RMN du Neuromuscular Investigation Center, vous serez en charge des aspects de post‐traitement des données, autant pour le développement de nouvelles techniques que pour la mise en place de méthodes fiables pour le suivi des patients.
Missions:
Développer ou améliorer des méthodes de post‐traitement d’imagerie par RMN pour le cas spécifique des muscles.
Contribuer à l’amélioration des techniques d’acquisition, notamment par l’implémentation de méthodes modernes de reconstruction d’images de type compressed sensing et fingerprinting.
Garantir la qualité des mesures réalisées dans le cadre d’études cliniques par la mise en place et le maintien d’outils informatiques pour le suivi des patients par des méthodes quantitatives.
CDD temps plein de 18 mois
2018/06/13 – CDD Spécialiste en traitement des images RMN
Au sein du laboratoire de RMN du Neuromuscular Investigation Center, vous serez en charge des aspects de post‐traitement des données, autant pour le développement de nouvelles techniques que pour la mise en place de méthodes fiables pour le suivi des patients.
Missions:
Développer ou améliorer des méthodes de post‐traitement d’imagerie par RMN pour le cas spécifique des muscles.
Contribuer à l’amélioration des techniques d’acquisition, notamment par l’implémentation de méthodes modernes de reconstruction d’images de type compressed sensing et fingerprinting.
Garantir la qualité des mesures réalisées dans le cadre d’études cliniques par la mise en place et le maintien d’outils informatiques pour le suivi des patients par des méthodes quantitatives.
CDD temps plein de 18 mois
Associate Scientist – Postdoctoral position, Lyon Area
This post-doctorate (18 months contract) is dedicated to develop in vivo imaging techniques to increase speed end robustness of the evaluation of new vaccines and adjuvants, especially in term of efficacy and bio-distribution.
KEY ACCOUNTABILITY:
Identify bio-markers, immune cells and pathways in order to assess the bio-distribution of the components in collaboration with IDMIT (Infectious Disease Models for Innovative Therapies).
Design and perform in vivo imaging studies for mRNA vaccines and new adjuvants projects in collaboration with RNCS (Research and Non Clinical Safety) teams.
This includes:
- Tag specific bio-markers, antigens and adjuvants.
- Design and perform in vitro studies to validate the techniques
For in vivo studies:
- Design experiments and draft protocols. Ask the authorization to the ethics committee
- Realize the in vivo phase on rodents or Non-Human Primates
- Analyze data with dedicated tools (like Living image software) and write appropriate reports
- Present conclusions to internal scientific committees
- Support in vivo imaging activities for other high prioritized projects
- Be a referent for technical aspects on in vivo imaging technologies like manage relationships with the supplier (PerkinElmer) of the IVIS Spectrum CT in Marcy L’Etoile (optical + 3D computerized tomography imaging), organize and monitor regular maintenance and decontaminations of the bioimaging laboratory and imaging devices.
- Support the development of in vivo Confocal Laser Endo-microscopy within Sanofi Pasteur with for example the Cellvizio Lab system from Mauna Kea to be tested on site.
MAJOR CHALLENGES:
Level 2 and 3 bio-containment facilities with a significant diversity of housed species (rodents and non-rodents) involving compliance to:
- rules of hygiene and safety of the sites
- procedures concerning the welfare and environment of animals
- French and European legislation concerning housing and experimentation on animals
- Sanofi charter on the protection of animals
- High technology level in vivo imaging devices to manage including:
a Photon Imager from Biospace lab with bioluminescence and fluorescence optical imaging modalities
an IVIS Spectrum CT from PerkinElmer with optical modalities associated with X ray computerized tomography allowing 3 dimensions imaging.
This device requires radiation protection management and regular inspections by the French Nuclear Safety Agency, external controls, and internal radiation monitoring.
Note that there is a potential use of radio-labelled compounds in the CEA with specific regulation and security procedures.
The candidate needs an important customer orientation (RNCS & ARD) to be an effective technical and scientific support in bioimaging within the framework of R&D projects, taking into account the organization, objectives and projects of the AMB platform.
DIMENSION/ SCOPE
This position will have interactions with many people mainly within:
- RNCS in Marcy l’Etoile
- IDMIT: this includes potential periods during the mission when the Post-doctorate will have to work in the IDMIT center in Fontenay-aux-Roses.
- RNCS in Cambridge (mRNA projects)
Associate Scientist – Postdoctoral position, Lyon Area
This post-doctorate (18 months contract) is dedicated to develop in vivo imaging techniques to increase speed end robustness of the evaluation of new vaccines and adjuvants, especially in term of efficacy and bio-distribution.
KEY ACCOUNTABILITY:
Identify bio-markers, immune cells and pathways in order to assess the bio-distribution of the components in collaboration with IDMIT (Infectious Disease Models for Innovative Therapies).
Design and perform in vivo imaging studies for mRNA vaccines and new adjuvants projects in collaboration with RNCS (Research and Non Clinical Safety) teams.
This includes:
- Tag specific bio-markers, antigens and adjuvants.
- Design and perform in vitro studies to validate the techniques
For in vivo studies:
- Design experiments and draft protocols. Ask the authorization to the ethics committee
- Realize the in vivo phase on rodents or Non-Human Primates
- Analyze data with dedicated tools (like Living image software) and write appropriate reports
- Present conclusions to internal scientific committees
- Support in vivo imaging activities for other high prioritized projects
- Be a referent for technical aspects on in vivo imaging technologies like manage relationships with the supplier (PerkinElmer) of the IVIS Spectrum CT in Marcy L’Etoile (optical + 3D computerized tomography imaging), organize and monitor regular maintenance and decontaminations of the bioimaging laboratory and imaging devices.
- Support the development of in vivo Confocal Laser Endo-microscopy within Sanofi Pasteur with for example the Cellvizio Lab system from Mauna Kea to be tested on site.
MAJOR CHALLENGES:
Level 2 and 3 bio-containment facilities with a significant diversity of housed species (rodents and non-rodents) involving compliance to:
- rules of hygiene and safety of the sites
- procedures concerning the welfare and environment of animals
- French and European legislation concerning housing and experimentation on animals
- Sanofi charter on the protection of animals
- High technology level in vivo imaging devices to manage including:
a Photon Imager from Biospace lab with bioluminescence and fluorescence optical imaging modalities
an IVIS Spectrum CT from PerkinElmer with optical modalities associated with X ray computerized tomography allowing 3 dimensions imaging.
This device requires radiation protection management and regular inspections by the French Nuclear Safety Agency, external controls, and internal radiation monitoring.
Note that there is a potential use of radio-labelled compounds in the CEA with specific regulation and security procedures.
The candidate needs an important customer orientation (RNCS & ARD) to be an effective technical and scientific support in bioimaging within the framework of R&D projects, taking into account the organization, objectives and projects of the AMB platform.
DIMENSION/ SCOPE
This position will have interactions with many people mainly within:
- RNCS in Marcy l’Etoile
- IDMIT: this includes potential periods during the mission when the Post-doctorate will have to work in the IDMIT center in Fontenay-aux-Roses.
- RNCS in Cambridge (mRNA projects)